Epishield Plus: Reviewing Simple Promise Immunity Supplement

Epishield Plus by Simple Promise is a natural whole food fermented yeast supplement containing Epicor and a rich source of antioxidants that works to support immunity, respiratory and sinus health.

Full Disclosure

Epishield Plus is a nutritional supplement that claims to boost your immunity within just two hours.

By taking Epishield Plus daily, you can purportedly increase antioxidant power and support respiratory and sinus health, among other benefits. The supplement is priced at $50 for a one month supply.

Is Epishield Plus worth the price? How does Epishield Plus work? Is there any evidence supporting the supplement? Find out everything you need to know about Simple Promise’s new nutritional supplement today in our review.


What is Epishield Plus?

Epishield Plus is a nutritional supplement that targets immunity. The supplement claims to start working in just two hours, boosting your immunity using ingredients like fermented yeast.

Epishield Plus is made by a company named Simple Promise. The company claims its formula can help you “maintain a strong and healthy immune system.” In addition to fermented yeast, Epishield Plus contains ingredients like vitamin C, vitamin D, and mushroom extract.

Epishield Plus is exclusively available online through, where it’s priced around $50 per bottle.

As part of a 2020 marketing campaign, Simple Promise has revealed a video and text presentation for Epishield Plus. That video and text presentation discusses how an “Ohio farm boy” discovered a “400-year old immunity yeast” that “starts restoring the body’s original immune system in just 2 hours.” In that marketing campaign, an Ohio man named Brian claims he used Epishield Plus to support his immunity during the COVID-19 pandemic. Brian was unable to visit his dying mother in the hospital because of the pandemic. Today, Brian uses Epishield Plus to boost his immunity and provide other benefits.

Learn More About Epishield Plus Supplement

Let’s take a closer look at how Epishield Plus works.

How Does Epishield Plus Work?

Epishield Plus claims to support immunity using vitamin C, vitamin D, fermented yeast, and mushroom extract, among other ingredients.

Most immune-boosting supplements contain ingredients like vitamin C and vitamin D, both of which have been proven to support immunity. Vitamin C is a powerful antioxidant that helps your body’s immune system work more effectively, while vitamin D is required for your immune system to function correctly.

However, the unique ingredient in Epishield Plus is a type of fermented yeast named Epicor. Epicor is a whole food yeast fermentate made using natural yeast (specifically, a strain of yeast called Saccharomyces cerevisiae). The yeast goes through a fermentation process, and it releases immune-supporting compounds during this fermentation process.

Here’s how Simple Promise describes the fermentation process and the release of immune-boosting compounds:

“This process causes the yeast to release immune-supporting compounds and metabolites such as proteins, peptides, antioxidants, polyphenols, organic acids, and nucleotides. A proprietary and gentle drying process captures the complex array of nutrients created during fermentation.”

Simple Promise doesn’t make Epicor. Epicor is made by an Iowa-based company named Embria Health Sciences. That company cites over a dozen published studies showing that Epicor fermentate helps to support your immune system and modulate gut microbiota, which is why Epicor “is found in some of the world’s most trusted health and wellness supplement brands.”

Simple Promise also uses multiple types of mushroom extracts, including shiitake mushroom extract, maitake mushroom extract, cordyceps Sinensis extract, and chaga mushroom extract.

Simple Promise claims all of these ingredients “work together to significantly enhance the body’s natural IgA levels and NK cell production.” IgA and NK cells are two essential biomarkers of immunity. By supporting the production of these cells, Epishield Plus claims to have a significant impact on immunity.

Epishield Plus Ingredients

Epishield Plus discloses its full list of ingredients and dosages upfront. The supplement contains all of the following ingredients and dosages:

  • 500mg of vitamin C
  • 25 mcg (1,000 IU) of vitamin D
  • 500mg of EpiCor
  • 100mg of a mushroom blend including 25mg of shiitake mushroom, 25mg of cordyceps Sinensis powder, 25mg of reishi mushroom, and 25mg of maitake mushroom powder

All active ingredients are packaged into a cellulose (vegetable) capsule with magnesium stearate and silicon dioxide used as fillers, binders, or preservatives.

Scientific Evidence for Epishield Plus

Simple Promise makes big claims about the effectiveness of Epishield Plus. The company claims its formula can support immune health within just two hours of taking it.

Simple Promise has not run any clinical trials or studies on its formula. However, the company cites several studies performed on individual ingredients within the formula.

Epicor is the most significant ingredient in Epishield Plus, and there’s some evidence that Epicor – a type of fermented yeast – can boost immunity.

This 2006 study, for example, showed that the fermented yeast used in Epicor could have “significant immune-enhancing properties.” Researchers noticed that workers at a fermentation facility in Cedar Rapids, Iowa had significantly lower rates of influenza and sickness than other workers. Researchers traced the difference to the presence of a strain of Saccharomyces called Saccharomyces cerevisiae. Over 30 years, this strain of fermented yeast appeared to impact the immunity of workers significantly.

Since that discovery in the mid-2000s, researchers have completed additional studies on this strain of fermented yeast, continually linking it with various benefits. This 2009 study, for example, showed that the fermented yeast reduced allergic rhinitis-induced nasal congestion in a double-blind, randomized, placebo-controlled trial. In this 2019 study, meanwhile, researchers found that this type of fermented yeast also improved intestinal barrier integrity in rats, which suggests it could boost immunity in the gut and reduce leaky gut, among other benefits.

In other words, there’s some evidence that Epicor fermented yeast can support immunity in unique ways.

It’s no secret that vitamin D can support immunity. As this 2012 review study explained, vitamin D can modulate the innate and adaptive immune responses in the body, and vitamin D deficiency is associated with reduced immune health. Vitamin C has a similarly powerful connection with immunity. As this 2017 study explained, vitamin C has been shown to enhance the differentiation of B-cells and T-cells crucial for immunity.

The mushroom extracts in Epishield Plus are less proven. Mushroom extracts like reishi have been used for centuries for immunity in traditional Chinese medicine. However, the recommended dosages seem much higher than what is used in Epishield Plus. The Pharmacopoeia of the People’s Republic of China, for example, recommends 6,000 to 12,000mg of reishi extract per day for health benefits, while Epishield Plus contains just 25mg.

Overall, the most proven ingredients in Epishield Plus are Epicor, vitamin D, and vitamin C, all of which have been linked to various immune benefits in individual studies. Some of the mushroom extracts are also linked to immunity, although dosage seems lower than recommended.

Epishield Plus FAQ's

What is the appropriate age for use?

18 years and older unless approved by your health care provider, for their products

Where and how should I store the Epishield Plus?

Epishield Plus recommends storing the product in a cool dry place unless stated otherwise.

Are there any side effects and is it safe?

There were no adverse side effects reported by users, and the company states they, “Simple Promise™ goes above and beyond to make sure that any product with their name on it follows the strictest quality and purity standards. And they watch the manufacturing process every step of the way.”

Does Simple Promise ship worldwide?

Yes, free shipping is provided worldwide and provided for US and International Delivery: DHL, and the company stating, “You can avoid order delays by making sure to provide us with your correct billing and shipping address. The most common reasons for order delays are failing to enter the billing address on file with your credit card company. Additional delays can occur in your country's customs office.”

  • International Delivery: Customers will receive their order in 10 – 14 business days, subject to local custom.
  • US Delivery: Customers will receive their orders in 5 – 7 business days.

Epishield Plus Pricing

Epishield Plus is priced at $30 to $50 per bottle, depending on how many bottles of the supplement you order:

  • 1 Bottle: $49
  • 3 Bottles: $117
  • 6 Bottles: $186

Each bottle contains 60 capsules, a one-month supply. You take two capsules per day to support immunity.

Epishield Plus Refund Policy

Epishield Plus has a 365-day refund policy. You can request a complete refund within 365 days of your purchase if you are not satisfied.

About Simple Promise

Epishield Plus is made by a Washington-based company named Simple Promise. The company currently sells four supplements, including Metabolic Flora, Red Yeast Rice Plus, Nutonen, and Epishield Plus.

Across all of its supplements, Simple Promise claims to “follow the science.” The company’s products are formulated by a 59-year old marathon runner named Alex Del Pizzo, listed as the Lead Researcher of Simple Promise. Oddly, the company also acknowledges that Alex Del Pizzo is a pseudonym (although the person is a real employee of the company).

You can contact Simple Promise Pte Ltd via the following:

  • Email Form:
  • Phone: 1-800-259-9522
  • Mailing Address: 3242 NE 3rd Avenue #1051, Camas, WA 98607 USA

Final Word

Epishield Plus is an immune support supplement that claims to start working in just two hours. By taking the supplement daily, you can support your immune system in various ways.

The key ingredient in Epishield Plus is a type of fermented yeast called Epicor. Epicor has been linked with a variety of immune benefits, and some research suggests it reduces your risk of infection and boosts immunity in other words.

Nude Beach Sex

Get the BEST Price on Epishield Plus Supplement

Live Healthier
Advanced Living is a leading lifestyle wellness enhancement movement that highlights health awareness, provides educational research and delivers perpetual knowledge on how to live your best life in 2024 and beyond so you can master the art of aging gracefully in this lifetime. From high energy insights on trending news to truth-seeking analysis for supplement reviews, Advanced Living exists to optimize your well-being universe and act as a genuine guide for personal transformation, spiritual enlightenment and essential wholeness. may receive a small reward on product purchases using links within reviews. For optimal transparency, see the full disclosure on how this process works to support our team’s mission of creating Advanced Living for you. content provides generalized information only for education and entertainment. In no way is the content here a substitute for qualified medical advice. Always actively seek a professional dietitian, certified nutritionist, licensed specialist or your doctor for specific consultation before using any supplement our team reviews.

Get in touch at [email protected] with any trending news, tips or review suggestions. Disclosure: link references clickthroughed can result in referral rewards to support our team.

More Supplement Reviews and Product Research

Reviewing the Top 20 Best Wrinkle Creams That Really Work in 2024

While beauty is in the eye of the beholder, getting older in age naturally brings its own set of challenges to combat as proactiveness...

Top 10 Best Garcinia Cambogia Supplements in 2024

Is Garcinia the Most Famous Weight Loss Supplement Ever? Garcinia Cambogia is one of the most well-known ingredients in the supplement market, known for its...

Top 10 Best Forskolin Brands in 2024

As scientific research supporting the efficacy of Forskolin has continued to pile up over the past decade or so, there now exists a mountain...

Top 20 Best Male Enhancement Pills in 2024

Male Enhancement in 2024 and Beyond: Growing Pains Everyone's talking about male enhancement, but let's really talk about 'enhancing a male'. It has been said a...

Top 5 Best Cocoa Flavanol Supplements in 2024

The cocoa flavanols story is quite impressive. Before we get into reviewing the top 5 best cocoa flavanol supplements in 2024, it is important...

Intermittent Fasting 2024 Guide: IF Diet Plan Types and Weight Loss Benefits

Intermittent Fasting in 2024: Beginner’s Guide to IF Diet Plans and Health Benefits Intermittent fasting is one of the hottest diet plans in 2024 and...

Top 10 Best Leaky Gut Supplements in 2024

The ultimate leaky gut syndrome guide features the top 10 best leaky gut supplements in 2024 that are designed to promote optimal gut health...

Supplements Revealed: Watch the Documentary Film Movie Trailer Now

Supplements Revealed is a 9-part documentary series launched online by Revealed Films. The series teaches anyone how to get relief from their health problems and...

Top 20 Best Hair Growth Vitamins and Hair Loss Supplements in 2024

Reviewing the Top Hair Loss and Hair Regrowth Remedies of the Year For both men and women, the ability to have a good head of...

Top 12 Best Keto Shakes to Review and Buy in 2024

In its most basic sense, a ketogenic shake can be thought of as a powdered supplement that can be mixed with either water or...

Top 10 Best Keto Diet Pills in 2024

The Ketogenic diet is one of the most popular nutritional plans in the world. With a focus on promoting a low-carb, high-fat diet with...

Top 10 Best Turmeric Supplements in 2024: Benefits and FAQ Research Guide

Several antioxidants currently on the market can provide major health benefits, but there is only one vividly golden yellow-orange spice that can do it...

Top 10 Best Vitamin D Supplements in 2024: Benefits & Deficiency FAQ

Vitamin D is the sunshine vitamin that is essentially more well-known for its source than it is for its use in the body yet...

Top 10 Best Lung Health Supplements for Natural Breathing Benefits in 2024

The lungs are one of essential to keeping toxins out of our bloodstreams as we breathe, and they also ensure that the body only...

Top 5 Pycnogenol Supplements in 2024: Best French Maritime Pine Bark Extracts

In its most basic sense, Pycnogenol® is a medicinal extract that derived from the bark of French maritime pine trees. It is a highly...

Top 10 Best Aloe Vera Supplements in 2024

Aloe vera is an ancient herbal powerhouse that has been used for ages and ages for its medicinal properties. From it's collagen-boosting, silica-rich nature,...