Top 10 Best Medicinal Mushroom Supplements of 2024

Reviewing the top 10 best medicinal mushroom supplement brands of 2024, plus a research guide on the most popular questions about the magic of shiitake, cordyceps, maitake, chaga and reishi extracts.

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The use of mushrooms for medicinal ends is still a relatively new trend, medicinal mushrooms are quickly becoming one of the most diverse sources of natural medicine available on the market today. These unique solutions can often help consumers with nearly any ailment, improving the immune system’s performance, reducing anxiety, and helping with mental clarity. Some sources say that it is even possible to improve athletic performance.

Mushrooms are fungi that offer some of the most effective defenses against common diseases, which makes them an ideal natural remedy for users looking to improve their overall wellness. They are high in key molecules that have been known to potentially even fight cancer cells, including lectins and beta-glucans. They’ve been consumed for thousands of years for these medicinal properties. But despite the lasting impacts and proliferation of this form of natural treatment, not all mushroom supplement brands are created equally.

This product guide will introduce readers to the top medicinal mushroom brands on the market today. Our product lists are not definitive, but should serve as a starting point in their own product research.


Why Are Medicinal Mushroom Supplements Important?

Medicinal mushrooms come with a substantial amount of benefits, primarily for the immune system. Mushrooms are packed with antioxidants, which help to reduce the damage that free radicals can impose on the body. In a 2010 study, chaga mushrooms were even shown to have anti-aging effects, reducing stress and even preventing certain types of cancer cells from flourishing.

Reishi mushrooms have similar effects, preventing damage to the cells and improving the response of the immune system. Turkey Tail and Shiitake mushrooms have both been linked to improving the immune systems of patients with cancer too.

Cordyceps mushrooms offer antioxidant support in the body as well, but they are primarily used to boost energy levels. In a study with lab mice, it demonstrated its ability to reduce blood sugar levels, which is especially helpful to consumers with diabetes or with a heightened risk of diabetes. To clear the mind, the lion’s mane mushrooms offer the best reaction of this group. It may also prevent short term memory loss associated with aging.

When it comes down to making a decision on which formula to integrate into any lifestyle, this list offers ten supportive remedies to start with.

Top 10 Best Medicinal Mushroom Brands

Take a look below to explore some of the best medicinal mushrooms on the market. Again, this list is not objective, and our opinions and preferences might not align with your own. This guide should serve as a reference for your own research.

Genius Mushrooms

Genius Mushrooms

Genius Mushrooms are the top of the list for many reasons, starting with the reputation of the brand for their innovative designs. Each serving contains a variety of mushrooms to help with cognitive function and immunity, including lion’s mane, cordyceps, and reishi mushrooms. The formula is almost completely pure, only holding a few other ingredients that are critical for the structure of the capsules – cellulose and silica.

With high potency and purity, the formula offers 90 veggie capsules for $23.99. The remedy needs to be taken three times a day, one capsule per dose, with an eight-ounce glass of water. Furthermore, the creators recommend that this dose be taken approximately 20 minutes before a meal.

Get Genius Mushrooms on Amazon

Onnit Shroom Tech

Onnit Shroom Tech

The medicinal mushroom extract from Onnit Shroom Tech moves away from the approach of Genius Mushrooms, in that it focuses on supporting athletic performance over immunity. It doesn’t have a combination of mushrooms like its predecessor, but it includes multiple herbal supplements to amplify its use of the cordyceps mushroom. Some of those herbs include green tea extract, ashwagandha, chromium, and red algae. It’s hardly the purest supplement on this list, but it helps the user with their focus and reaction time in the gym.

For the 84-capsule bottle (which lasts for 21 sessions), the total cost is $55.95, and it can be purchased through

Get Onnit Shroom Tech on Amazon

DailyNutra Mushroom Defense Formula

DailyNutra Mushroom Defense Formula

The target result of the DailyNutra Mushroom Defense Formula is to support the immune system. Much like Genius Mushrooms, it offers the power of multiple mushrooms – reishi, chaga, shitake, maitake, and turkey tail. To improve the effectiveness of the formula, the creators added a dose of beta D-Glucans as well. Every ingredient in this blend is completely organic, appealing to the clean-living crowd.

This entirely vegan formula offers 90 capsules per bottle for a 45-day supply. It can be found from multiple third-party websites, but Amazon offers it for $29.99 as one of their top choices for a “mushroom defense formula.”

Get DailyNutra Mushroom Defense Formula on Amazon

Naturealm Sacred 7 Mushroom Extract Powder

Naturealm Sacred 7 Mushroom Extract Powder

The Naturealm Sacred 7 Mushroom Extract Powder offers one of the highest numbers of mushroom types with 7 different species – lion’s main, reishi, cordyceps, maitake, shitake, turkey tail, and chaga. However, this number of species leaves some concern over how effective and concentrated they are. Still, Naturealm manages to include 100mg per servings for each one.

Since the product is in powder, consumers can add it to drinks, food, coffee, and other recipes, which is especially helpful for consumers that don’t like to swallow a capsule. This product is available for $42.99 for an eight-ounce bag on Amazon.

Get Naturealm Sacred 7 Mushroom Extract Powder on Amazon

Freshcap Mushroom Thrive 6 Mushroom Extract Powder

Freshcap Mushroom Thrive 6 Mushroom Extract Powder

The Freshcap Mushroom Thrive 6 Mushroom Extract Powder brings the power with multiple mushroom types in the powder extract. The types – which include lion’s mane, reishi, cordyceps, chaga, turkey tail, and maitake – come with an unusual spin on supplement powders, improving bioavailability with both mycelium and no hot water extraction process.

There are no extra ingredients in this two-ounce bag, which is available on Amazon for $23.95. Consumers only need half a teaspoon to get a full serving.

Get Freshcap Mushroom Thrive 6 on Amazon

Host Defense Multi-Mushroom Capsules

Host Defense Multi-Mushroom Capsules

The Host Defense Multi-Mushroom Capsules offers 17 mushroom species and a ton of health benefits. Even with these benefits, there’s still a total of 18 natural ingredients, which tones down the effects of the mushroom strains a bit. Still, it boasts massive immunity support and comes with a range of probiotics, antioxidants, and healthy enzymes.

To condense the formula, consumers only need to take two capsules a day to get the desired benefits from the 120-capsule bottle. It can be found on Amazon for a retail cost of $61.23, but there’s also a 30-count and 60-count bottle available if consumers want to try a smaller investment first.

Get Host Defense Multi-Mushroom Capsules on Amazon

Maju’s Mental Mushroom Powder Extract

Maju’s Mental Mushroom Powder Extract

While the other formulas on this list focus on immunity or even athletic performance, Maju’s Mental Mushroom Powder Extract is all about the mind. Promoting healthier cognitive function and brain health, it includes extracts from four different mushroom species, along with Maju’s Mental Blend. The powder comes with its own scoop to measure out, but it can be added to coffee or tea in the morning for all-day support.

The total cost of an 80-gram bag is $27.99 on Amazon. Since the serving size is just 2.5 grams, this package should last the user for quite a while.

Get Maju’s Mental Mushroom Powder Extract on Amazon

Nutriflair Mushroom Supplement

Nutriflair Mushroom Supplement

The Nutriflair Mushroom Supplement is an entirely vegan formula, offering seven different mushroom species in a blend that is set to offer brain and immunity support. According to the website, it also is helpful in promoting healthy blood sugar and cholesterol levels, while promoting better focus and memory retention, acting as a low-key nootropic formula as well. It also helps with stress and poor sleeping.

Each bottle contains 30 servings, and consumers need to take a total of three capsules a day to get the desired results. The 90-capsule bottle is available for $17.99 on Amazon.

Get Nutriflair Mushroom Supplement On Amazon

BioSchwartz Premium Mushroom Complex

BioSchwartz Premium Mushroom Complex

The BioSchwartz name is synonymous with trustworthiness and effectiveness in the supplement industry, and their Premium Mushroom Complex doesn’t disappoint. With eight different mushroom species, the formula is entirely organic and boasts many benefits – better mental clarity, increase immunity, more energy, and more. The formula even comes with a money-back guarantee, but it comes with a lot of positive reviews that suggest that consumers probably won’t be returning it.

A single serving of the Premium Mushroom Complex takes two capsules, and the 60-capsule bottle can be purchased for $18.97. It’s even listed on Amazon as one of their Choice picks for mushroom supplements.

Get BioSchwartz Premium Mushroom Complex on Amazon

Real Mushrooms Lion’s Mane Mushroom Powder

Real Mushrooms Lion’s Mane Mushroom Powder

The majority of the focus in the Real Mushrooms Lion’s Mane Mushroom Powder is on the species directly in the name of the formula – lion’s main. However, it remains one of the most successful formulas on the list. There’s a substantial number of scientific studies listed, which offers consumers a high level of confidence that may not be afforded to some of the other options.

For 120 capsules, consumers will find the powder-based supplement on Amazon for $29.95. Since consumers only need two capsules a day, the bottle should last for about two months with regular use.

Get Real Mushrooms Lion’s Mane Mushroom Powder on Amazon

Frequently Asked Questions About Medicinal Mushroom Blends

Misinformation is prevalent in the growing medicinal mushroom industry. This section should serve as a resource by answering many of the most commonly asked questions about medicinal mushrooms and medicinal mushroom blends.

Q: How can medicinal mushrooms help you?

A: The specific benefits offered by medicinal mushrooms depends on the type and strain of mushroom you choose to buy. Many mushroom blends include multiple strains, which often work together to promote a number of specialized health benefits. Mushrooms can promote improved energy levels, heightened immune efficiency, lower blood pressure, and more.

Q: What is the best medicinal mushroom to take?

A: This depends mostly on what you want to get out of your medicinal mushroom supplement. Lion's Mane mushrooms are particularly popular, and they can improve mental acuity, delay the onset of dementia, and even help to minimize anxiety and panic disorder. The wide range of benefits make Lion's Mane a solid contender for the most useful medicinal mushroom.

Q: Are medicinal mushrooms scientifically supported?

A: Yes! Studies over multiple years have consistently found that some mushrooms can have impressive effects on the mind and body alike. Some scientists are careful to warn users that mushrooms should not be used as a replacement for existing medication. We concur; mushrooms can complement treatment plans, but should not replace them.

Q: Should you speak to your doctor before using medicinal mushrooms?

A: Generally, yes. Mushrooms rarely interact negatively with medication plans, but interactions may still occur. Consult your physician before beginning any new alternative medicine regimen.

Q: How do you use medicinal mushroom supplements?

A: These supplements can be used in a variety of ways. The specific method of ingestion depends on both the type and brand of mushrooms you purchase. Some mushrooms come in capsules, while others are powdered and must be mixed with liquid to be consumed.

Final Thoughts

Mushrooms are gaining traction as a simple way for consumers to improve psychological and physical conditions. While mushrooms should not be used as a supplement for serious medication in the case of genuine illness, the benefits of mushroom supplementation are multiple and clearly established within the medical industry.

Our guide should help to give you all the tools you need to begin searching for the medicinal mushroom blend that's right for you.

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