Yohimbine – Latest Research Included

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What exactly is yohimbine and what are its uses?

Yohimbine is a prescribed medicine for treating men who have impotence (erectile dysfunction) caused by cardiovascular conditions, diabetes, or psychological reasons. However, there are few studies on its effectiveness and more efficient drugs like phosphodiesterase-5 inhibitors are available to treat erectile dysfunction.

Yohimbine is also used as a drug on the streets, advertised as an aphrodisiac hallucinogen, to help with weight loss, and for many other reasons, but there isn't any scientific evidence that supports any of these applications.

Yohimbine is an alkaloid of plants extracted from the tree bark Pausinystalia Yohimbine is an evergreen tree that is native to central and western Africa. Yohimbine hydrochloride is a standard version of yohimbine that can be purchased as a prescribed drug throughout the U.S.

Yohimbe can be described as the P. Yohimbine bark extract used in a variety of herbal supplements. Few studies have been conducted on the safety and effectiveness of yohimbe as a dietary supplement, and its use is restricted in several nations.

Yohimbine is a drug that blocks alpha-2 adrenergic receptors. These are protein receptors on nerve cells that get stimulated when norepinephrine is released. It reduces the activity of the sympathetic nervous system (adrenergic) and boosts activities of the parasympathetic system (cholinergic), and results in a greater flow of blood into the penis and less flow of blood. This can help maintain an erection.


  • Don't use yohimbine in the following situations:
    • Hypersensitivity to Yohimbine
    • Schizophrenia and panic disorder are both a part of schizophrenia.
    • Kidney, liver, or heart illness
    • Blood pressure that is low (hypotension)
  • Yohimbine is not recommended for use by children and women.
  • Don't take yohimbine with food items that are rich in the amino acid tyramine, like liver, cheese as well as red wines.
  • Do not take yohimbine in conjunction with stimulant substances, such as caffeine and ephedrine-alkaloids. There are reports of seizures, kidney failure, and even death due to the use of these supplements in diets.

What are the possible side negative effects of Yohimbine?

Yohimbine's most frequent side effects are:

  • Dizziness
  • Headache
  • Flushing
  • Sweating
  • Nausea
  • Vomiting
  • Anxiety
  • Irritability
  • Drowsiness
  • Disorientation
  • The severity of panic attacks increases
  • Tremor
  • Seizure (with high doses)
  • An increase in blood pressure
  • Heart rate rapid (tachycardia)
  • A painful or prolonged sexual erection (priapism)
  • Rash
  • Hives
  • Hypersensitivity reactions
  • The amount of urine produced is reduced.

This isn't an exhaustive listing of all possible side reactions or adverse reactions that can occur due to using this medication.

Contact your doctor for advice from a medical professional regarding severe side effects or allergic reactions. You can also report any side reactions or health concerns to the FDA at 1-800-FDA-1088.

What dosages are there for Yohimbine?


  • 5.4 mg


Impotence, Aphrodisiac

  • 0.5-1 tablet/caplet 3 times a day

The recommended time for treatment is not more than 10 weeks.


  • The safety and effectiveness of this product is not confirmed.


  • Yohimbine overdoses can trigger anxiety, drowsiness, and disorientation, in addition to seizures and tremors at higher doses.
  • Overdose is treated using symptoms and supportive treatment. If you suspect that you have overdosed you should immediately seek medical attention or call Poison Control.

What other drugs can interact with yohimbine?

Inform your doctor about the medications you're currently taking. They will be able to provide you with any potential interactions with drugs. Do not abruptly start taking, stop or change the dose of any medication, without your doctor's advice.

  • Some of the most serious interactions with yohimbine comprise:
  • isocarboxazid
  • linezolid
  • phenelzine
  • selegiline transdermal
  • tranylcypromine
  • Yohimbine is known to cause serious interactions with at least 30 different substances.
  • Yohimbine can have a moderate interaction with most 168 different medications.
  • Some of the mild interactions of yohimbine are:
  • American Ginseng from the United States
  • desmopressin
  • Eucalyptus
  • Guarana
  • Sage
  • Youba mate

The above drug interactions and adverse effects aren't the only possible interactions. For more information about drug interactions, check out RxList's Drug Interaction Checker.

It is essential to inform your pharmacist, doctor, or health professional of any prescription or over-the-counter medicines you take and the dosage of each, and make a note of all the details. Talk to your doctor or health care professional for any concerns regarding the medication.

The mother and the baby

  • Yohimbine is not a suitable choice for pregnant or nursing mothers who should definitely not consume it.

What else do I need to be aware of about the yohimbine?

  • You should take yohimbine as a standard tablet form only when prescribed by your physician and according to the directions.
  • Be sure to store the item away from the reach of children.
  • Do not take yohimbine/yohimbe extracts that can be found in herbal supplements Natural products aren't necessarily secure.
  • Herbal supplements don't undergo strict evaluation by the FDA to ensure their safety and efficacy. There are often differences between the labels and the actual amount of yohimbine in herbal products. A study of 49 products containing yohimbine discovered that only three had an amount equivalent to the amount stated by the manufacturer on their labels.


Yohimbine is a prescribed medication that is used for treating male impotence (erectile dysfunction) caused by vascular or diabetes conditions or psychological causes. Yohimbine is also utilized as a street drug being promoted as an aphrodisiac hallucinogen, as well as for weight loss, but there is no research-based evidence. Yohimbine is a prescription drug for treating men's impermanence (erectile dysfunction) caused by vascular conditions, diabetes, or psychological reasons. Yohimbine is not recommended for use by children or women. Yohimbine is not recommended for consumption by women and nursing mothers or pregnant women definitely should not consume it.

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