Circ02: Review Advanced Bionutritionals Nitric Oxide Booster

Circ02 by Advanced Bionutritionals is a natural nitric oxide booster that enhances oxygen and circulation support using MIT Scientist proven ingredients that make this a leading NO2 supplement.

Full Disclosure

Circ02 is a nutritional supplement that claims to boost oxygen and circulation.

By taking Circ02 daily, you can purportedly raise nitric oxide (NO) levels. The formula uses beetroot powder, vitamin C, and vitamin B12, among other ingredients, to promote healthy circulation.

Does Circ02 really work? How does Circ02 boost oxygen and circulation? Find out everything you need to know about Circ02 today in our review.


What is Circ02?

Circ02 is a circulation-boosting nutritional supplement from Advanced Bionutritionals. The supplement claims to promote nitric oxide (NO) levels in your bloodstream, raising the flow of oxygen, blood, and nutrients throughout your body.

Nitric oxide is a crucial molecule. Your body produces nitric oxide daily to support various body functions. Nitric oxide promotes circulation by widening blood vessels. Some people take nitric oxide supplements to lower blood pressure. Others take nitric oxide supplements before a workout to increase ‘pump.’

Circ02, like other nitric oxide supplements, contains vitamins, amino acids, and plant extracts that could boost nitric oxide levels in the body. By taking Circ02 daily, you can purportedly support the healthy production of nitric oxide, which leads to other benefits.

Circ02 is made by a Norcross, Georgia-based company named Advanced Bionutritionals. You can exclusively buy Circ02 online through, where it’s priced at around $50 for a one-month supply (30 lozenges).

How Does Circ02 Work?

Circ02 comes in the form of a lozenge. You take one lozenge daily, allowing the lozenge to dissolve on your tongue. Your body absorbs the active ingredients, and you experience certain benefits.

Circ02 claims to offer all of the following features and benefits:

  • Supports healthy circulation
  • Supports a healthy immune system
  • Promotes nitric oxide levels that impact the health of every cell, tissue, and organ
  • Boosts the formation of bone while slowing down bone breakdown
  • Promotes healthy cholesterol levels
  • Lifts mood and wellbeing to help you get more joy out of life

In a testimonial on the Circ02 sales page, one user claims her blood pressure “became normal” after taking Circ02 tablets. Another customer claims to use it to boost energy, while someone else takes it before gym workouts.

Whether lowering blood pressure or boosting energy, Circ02 claims to support various bodily functions. Let’s take a closer look at the ingredients to determine how Circ02 works.

Circ02 Ingredients

Circ02 contains six ingredients, including many of the same ingredients found in other nitric oxide supplements.

Each lozenge contains the following ingredients:

  • 100mg of vitamin C (167% DV)
  • 1000mcg of vitamin B12 (16,667% DV)

420mg of a proprietary nitric oxide blend containing beetroot powder, hawthorn berry extract, L-citrulline, and sodium nitrite

Inactive ingredients in the lozenge include mannitol, modified cellulose, xylitol, natural flavors, magnesium vegetable stearate, stevia, silica, and natural carmine color.

Scientific Evidence for Circ02

Most of the ingredients in Circ02 have been shown to boost nitric oxide or widen blood vessels in some way. However, some of the dosages seem too low to be effective.

Advanced Bionutritionals has not launched any studies or clinical trials on Circ02. Instead, they cite studies performed by third-party researchers on the individual ingredients within Circ02. Let’s break down the scientific evidence to see if Circ02 works as advertised.

First, Advanced Bionutritionals cites this 2008 study on L-citrulline published in The British Journal of Nutrition. In that study, researchers analyzed the effects of citrulline on humans. Eight healthy males took 2g, 5g, 10g, or 15g of citrulline, and researchers analyzed the effects. Researchers found oral citrulline supplementation raised citrulline in the body with no apparent side effects, although scientists did not analyze the effect of supplementation on blood pressure or nitric oxide.

Advanced Bionutritionals also cites this 2017 study as proof Circ02 works as advertised. In this study, 25 older adults took 6g of citrulline per day to test its effects on blood flow and blood pressure. Researchers found that L-citrulline “has a modest effect of improving muscle blood flow during submaximal exercise in older men.”

Both of these cited studies used a much larger dosage than Circ02. Circ02 contains just 420mg of a proprietary blend with L-citrulline as the third-listed ingredient. That means there may be just 50mg to 200mg of L-citrulline inside the supplement. The studies above used doses of 2,000mg to 15,000mg – or 10x to 75x the dose found in Circ02.

Many people take L-citrulline supplements to raise nitric oxide. It’s the most common ingredient in many pre-workout formulas. However, these supplements typically contain 2,000 to 6,000mg of L-citrulline per serving – again, many times higher than the dose found in Circ02.

Circ02 also cites this 2006 study on hawthorn berry extract as proof that it has hypertensive effects (i.e., that it lowers blood pressure). In a randomized controlled trial, researchers gave 79 patients with type 2 diabetes 1,200mg of hawthorn extract or a placebo for 16 weeks. Researchers found that hawthorn berry had a hypertensive effect compared to the placebo.

Again, the study uses a much higher dose than Circ02. Circ02 has a total proprietary formula of 420mg – which means there’s likely less than 200mg of hawthorn berry extract in the formula. In comparison, the study above used 1,200mg – at least six times the dose used in Circ02.

Meanwhile, some of the most proven ingredients in Circ02 are vitamin C, vitamin B12, and beetroot powder. All three of these ingredients have been shown to support blood circulation and other benefits. Unfortunately, you can also find these ingredients in much cheaper supplements – an average multivitamin or beetroot powder contains a higher dose of these ingredients for less than $10 per bottle.

Advanced Bionutritionals cites other studies that use much larger dosages than Circ02, claiming that users can experience similar effects. Overall, Circ02 seems to contain the right ingredients – including ingredients proven to lower blood pressure and impact nitric oxide. However, the supplement uses doses that are 10x to 80x smaller than the doses used in studies. Based on this evidence, it seems unlikely Circ02 will have a significant effect on the body.

Circ02 Pricing

Circ02 is priced at $42 to $50 per box. Each box contains 30 lozenges. Here’s how pricing breaks down:

  • 1 Box: $49.95 + $6.95 Shipping
  • 3 Boxes: $134.85 + Free Shipping
  • 6 Boxes: $249 + Free Shipping

Circ02 Refund Policy

Circ02 comes with a 90-day money-back guarantee. You can request a complete refund within 90 days with no questions asked. Just return the bottle of Circ02 – even if it’s empty – to qualify for a refund.

About Advanced Bionutritionals

Advanced Bionutritionals is a nutritional supplement company led by Dr. Frank Shallenberger, a medical doctor with 41+ years of experience. Dr. Shallenberger is licensed as both a medical doctor and as an alternative medicine practitioner.

The company also has Janet Zand, O.M.D., L.Ac, Steve Kroening, ND, and Isaac Eliaz, MD, MS, L.Ac on its medical board.

Circ02 was specifically formulated by Dr. Janet Zand, a Doctor of Oriental Medicine, a board-certified acupuncturist, and a natural medicine practitioner with 25+ years of experience. Dr. Zand claims to work with movie stars and professional athletes in Hollywood and has published multiple books on natural health and healing.

You can contact Advanced Bionutritionals via the following:

  • Email: [email protected]
  • Phone: 800-791-3395
  • Mailing Address: PO Box 8051 Norcross, GA 30091-8051

In addition to Circ02, Advanced Bionutritionals makes dozens of supplements targeting antioxidants, bladder function, bone support, brain and memory support, detoxification, immune function, inflammatory response, joint health, and other body functions.

Final Word

Circ02 is a nutritional supplement that claims to boost nitric oxide (NO) levels within the body, increasing the flow of blood and oxygen throughout your circulatory system. Some people take Circ02 to lower blood pressure. Others take it before a gym workout.

Overall, Circ02 contains the right ingredients to boost nitric oxide and circulation. It contains proven ingredients like beetroot, L-citrulline, vitamin C, and vitamin B12. However, most of these ingredients are found at a much lower dose than what is used in other supplements and studies. Circ02 contains less than 420mg of L-citrulline, for example, when most supplements and studies use a daily dose of 4,000mg to 12,000mg.

At this price, you should be able to find a better nitric oxide boosting formula with higher dosages of the same ingredients. However, Advanced Bionutritionals offers a 90-day money-back guarantee, making it easy to request a complete refund if you are unsatisfied with your purchase.

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