Synbiotic 365: United Naturals Advanced Probiotic Formula Review

The Synbiotic 365 Advanced Probiotic Formula by United Naturals and Dr. Vincent Pedre, M.D. is a leading gut flora and digestive health supplement aimed to provide lasting relief, but what does the research say?

Full Disclosure

Synbiotic 365 by United Naturals is an Advanced Probiotic Formula created by Dr. Vincent Pedre, a certified medical doctor and founder of Pedre Integrative Health.

Considered a leading gut health expert and frequently appears on Good Morning America and Doctor Oz TV shows, Dr. Pedre got his degree from University of Miami School of Medicine after graduating with honors from Cornell.

Now, his holistic medicine approach, spanning over 20 years of physician experience, has turned to digestive and gut health, which birthed the highly-touted probiotic supplement, Synbiotic 365.

In case you have saw the many advertisements floating around the Internet for United Naturals' digestive health product, the Chief Wellness Officer is encouraging consumers to throw out your Ibuprofen now and start bulletproofing your bowels with a simple gut cleanse. Considered a functional medicine expert, he has also designed a ‘Gut C.A.R.E. Program' after going through personal irritable bowel syndrome issues for years, which is all about Cleansing, Activating, Restoring, and Enhancing gut health.

Let's take the time to research and review Synbiotic 365 probiotic supplement and see if the science matches up with the hype surrounding United Naturals advanced digestive gut health formula and the digestive superfoods presentation.


Synbiotic 365 Review: 2020 Product Research Guide

When the term “bacteria” is thrown around, consumers are surely to feel some form of uneasiness. Why? For the obvious reasons, that is, they are associated with terms like disease, infections, disgust, etc. So, when supplements like probiotics, which contain living bacteria, are suggested, the logic is surely not going to make any sense.

However, this is not the case. In fact, many studies have found evidence suggesting that specific kinds of bacteria (i.e. those found in probiotics) can aid in digestion and maintain a healthy gut. In particular, when live bacteria are delivered to the body, it works its way to the gut and is said to have a face-off with bad bacteria. The end goal is to rid one’s system of the bad by introducing the good and creating a balance.

With the Synbiotic 365 Advanced Formula, consumers are getting more than just probiotics, which is their first facet. What makes this dietary supplement a 3-in-1? What else is involved? The following review will look closely at the different facets that the Synbiotic 365 Advanced Formula houses and how its ingestion could potentially promote wellness.

Synbiotic 365 Ingredients

Created by United Naturals and formulated by Dr. Vincent Pedre, who's tagline is “nutrition from nature's cupboard”, the Synbiotic 365 Advanced Formula was developed as a dietary supplement that tends to one’s flora needs. Flora is often used to describe existing microorganisms within the human body (in this case, gut flora). With this supplement, consumers can expect to reintroduce balance in the gut flora, which in turn is said to limit food cravings, and exhaustion among others.

In a case of friendly bacteria versus harmful bacteria, if not dealt with accordingly, the balance becomes out of whack and can lead to major health mishaps and conditions like leaky gut, obesity and irritable bowel syndrome. This is why the three in one advanced probiotics formula found in United Naturals Synbiotic 365 supplement was created.

Let's cover the three main digestive superfoods Dr. Pedre covers; chicory root, Therapeutic Class Probiotics​ (​TCPs) and a dedicated Vitamin B Complex with all 8 vitamin B compounds.

What Makes the Synbiotic 365 a 3-in-1 Supplement?

Besides the inclusion of probiotics, the formula also houses prebiotics and B-vitamins. Prebiotics are classified as a type of fiber and typically occur in a number of vegetables and whole foods including bananas, garlic, whole grains, and asparagus to name a few.

They also serve as nutrition for probiotics, as the latter feeds on the former because of its nondigestible nature. Said fuel provided to the probiotics is expected to strengthen them, which is essential in fighting off the bad.

Then we have B vitamins, which are known to help the body breakdown carbohydrates, fats and proteins while ensuring that one’s digestive system properly functions. In addition, they are essential in maintaining good cholesterol levels. Interestingly, it is believed that B group vitamins are also created by the gut microbiota. These are said to contribute to one’s metabolism. Hence, Synbiotic 365 includes B vitamins in case the gut is imbalanced and incapable of producing vitamins.

These clinically proven ingredients of Vitamin B Complex, Therapeutic Class Probiotics and Chicory Root are where all of the probiotics, prebiotics and B-vitamins originate from.

What Else is There to Know About the Product's Formula?

It contains 14 different bacteria strains, most of which have been studied and found to help the digestive system.

Next, a specific B-vitamin has been included which supports digestive health and it is Vitamin B-12. Vitamin B-12 is an essential nutrient that ensures the proper functioning of the body. When consumers are low on this vitamin, not only are one’s energy and mood levels impacted but also will the digestive tract. To be more specific, vitamin B12 deficiency implies lack of red blood cells, which ultimately results in low levels of oxygen in the gut. So, if consumers experience diarrhea, headaches, or nausea, this could be part of the reason why.

Then comes the fact that the formula has been doctor-formulated, i.e. by Dr. Vincent Pedre. Dr. Vincent Pedre is a physician, who is also referred to as a “Functional Medicine Certified Practitioner”. It was supposedly his research that led to the combination of pre- and probiotics and B vitamins.

Here is a complete Synbiotic 365 supplement facts label to see all of the various ingredients and probiotic strains:

synbiotic 365 united naturals supplement facts

The certified organic (by Quality Assurance International), GMO-free and allergen-free product also boasts high-tech packaging with nitrogen-purged blister packs to ensure the live probiotic bacteria survive and guarantees a shelf life of 2 years without refrigeration. It is also made in the USA and claims to independently test every single capsule for potency, stability and purity in an FDA-approved lab. Dr. Pedre also insists there are zero side effects of using Synbiotic 365.

How Much Does Synbiotic 365 Advanced Formula Cost?

Users can buy Synbiotic 365 directly from

Consumers can choose between purchasing one box (30 servings for $45), three boxes (90 servings for $119) and six boxes (180 servings for $229). The prices are reasonable mainly because of its 3-in-1 formula. Oftentimes, $45 reflects the inclusion of one or two of the three components introduced in this dietary supplement, hence, consumers appear to be getting their money’s worth.

It is also easy to contact the company via phone or email:

Phone: 1-(844)-794-7728
Email: contact form on official website or use [email protected]

The nutritional health supplement company also offers a few other products to compliment their advanced probiotic formula:

It is also reassuring for users that all products come with a 60-day money back guarantee.

Frequently Asked Questions About Synbiotic 365

What is Synbiotic 365?

Synbiotic 365 is a 3-in-1 advanced probiotic dietary supplement by United Naturals. The intention behind this supplement is to support consumers who have or are currently experiencing poor digestive health (i.e. bloating, stomach aches, diarrhea, gas, etc.). Upon ingesting Synbiotic 365, consumers can anticipate a balanced gut flora, suppressed cravings and a clean source of energy.

How does Synbiotic 365 work?

Synbiotic 365 works in three ways, and this has a lot to do with the inclusion of prebiotics, probiotics and a rich source of vitamins, with primary focus on vitamin B12.

In order to rid one’s system of bad bacteria, which causes the imbalance in the gut, good bacteria called probiotics are needed. However, in the process of eliminating bad bacteria, some of the good bacteria also experiences damage. In this case, prebiotics are needed, which fuel and further strengthen the existence of probiotics.

Finally comes the family of B-vitamins, which are expected to shape the overall structure of the gut microbial communities that exist. For instance, a deficiency in vitamin B12 implies a lack of red blood cells, hence oxygen does not reach the gut. This is one of the main reasons why consumers experience bloating and stomach aches among others.

Together, the trio is expected to create a well-balanced gut health.

What are the ingredients in Synbiotic 365?

As per the nutritional facts, Synbiotic 365 includes three different categories of ingredients. They are as follows:


  • Thiamin (Vitamin B1) – 200% of Daily Value
  • Riboflavin (Vitamin B2) – 200% of Daily Value
  • Niacin (Vitamin B3) – 200% of Daily Value
  • Pyridoxine HCL (Vitamin B6) – 200% of Daily Value
  • Methylfolate (as calcium L-5-methyltetrahydrofolate) – 200% of Daily Value
  • Methylcobalamin (Vitamin B12) – 1000% of Daily Value
  • Biotin (Vitamin B7) – 200% of Daily Value
  • Pantothenic acid (Vitamin B5) – 200% of Daily Value

Probiotic Blend (20 Billion CFU per Capsule with 15 proven strains):

  • Lactobacillus gasseri BNR-17®
  • OPTI-BIOME B subtilis MB-40
  • Bifidobacterium lactis BIO-4™
  • Lactobacillus paracasei Lpc-37™
  • Lactobacillus plantarum Lp-115™
  • Streptococcus thermophilus St-21™
  • Lactobacillus casei Lc-11™
  • Lactobacillus reuteri
  • Lactobacillus salivarius Ls-33™
  • Lactobacillus rhamnosus Lr-32™
  • Lactobacillus gasseri Lg-36™
  • Lactobacillus fermentum
  • Bifidobacterium bifidum Bb-06™
  • Bifidobacterium longum Bl-05™
  • Saccharomyces boulardii

Prebiotic: the sole ingredient found under its prebiotic category is chicory root. Chicory root is deemed ideal simply because it contains approximately 68% of a prebiotic fiber called inulin. Inulin plays a significant role, as it not only promotes balance, but a number of studies have found it to serve as nutrition for the growth of good bacteria.

Other ingredients to be watchful of include Hypromellose and rice hull concentrate. While the latter is deemed a safe ingredient, the former lacks studies to make assertive claims regarding health implications.

How does Synbiotic 365 interact with allergies?

According to [1], who’ve spoken with the Founder of Synbiotic 365, the supplement has been deemed gluten free, safe for those diagnosed with Celiac disease, dairy- and lactose-free, GMO-free and contains no traces of eggs, nuts or soy.

How much does Synbiotic 365 cost?

Given that consumers have been advised to take one capsule daily, each box comes with 30 servings (i.e. one-month supply). Synbiotic 365 comes in one, three and six boxes, which cost $45, $119 and $229 all together respectively. That said, should the supplement not bring satisfactory results, United Naturals has offered a 60-day money back guarantee, hence there are no risks in testing its effectiveness.

Where can I buy Synbiotic 365?

To ensure neither quality is compromised nor consumers are scammed, it is best to purchase from United Naturals by clicking here. Additionally, there are perks to purchasing from the main manufacturer. For instance, they have a “Refer a Friend” program, where the consumer and their friend each get $30 towards their purchase.

Finally, if any doubts come up and consumers would prefer to have them clarified prior to a purchase, customer care can be reached either at 1-844-794-7728 or by leaving a message. Their support team has been trusted as being very responsive and reasonable.

Should Consumers Buy United Naturals Synbiotic 365?

While the Synbiotic 365 Advanced Formula contains prebiotics and probiotics and B vitamins, consumers should also consider whole foods. For instance, food like yogurt, kefir, sauerkraut, tempeh and miso are great sources of probiotics, whereas vegetables and whole grains contain prebiotics. As for B vitamins, they are found in almost all food groups including meat, whole grains, nuts and leafy vegetables.

Ultimately, relying solely on the dietary supplement will neither suffice nor will it be healthy. It is deemed unhealthy simply because too much of anything can be bad. Moreover, not all existing strains have been studied, so there might be a lack of evidence. Hence, including whole foods along with the supplement would be an ideal approach to a healthy gut and digestive system.

As for United Naturals Chief Wellness Officer, now based in New York City since 2004, Dr. Vincent Pedre is Board-Certified Internist and Functional Medicine Certified Practitioner who is also the author of a book titled, “Happy Gut: The Cleansing Program to Help You Lose Weight, Gain Energy, and Eliminate Pain“. Given the prominence of Dr. Pedre, who also teaches at the Mount Sinai School of Medicine, and the reputable status of United Naturals, the Synbiotic 365 Advanced Probiotics Formula appears to be a solid option to consider if you are experiencing any level of gut discomfort, pain or digestive problems.

Click here to check out the Synbiotic 365 probiotic supplement today

Live Healthier
Advanced Living is a leading lifestyle wellness enhancement movement that highlights health awareness, provides educational research and delivers perpetual knowledge on how to live your best life in 2020 and beyond so you can master the art of aging gracefully in this lifetime. From high energy insights on trending news to truth-seeking analysis for supplement reviews, Advanced Living exists to optimize your well-being universe and act as a genuine guide for personal transformation, spiritual enlightenment and essential wholeness. may receive a small reward on product purchases using links within reviews. For optimal transparency, see the full disclosure on how this process works to support our team’s mission of creating Advanced Living for you. content provides generalized information only for education and entertainment. In no way is the content here a substitute for qualified medical advice. Always actively seek a professional dietitian, certified nutritionist, licensed specialist or your doctor for specific consultation before using any supplement our team reviews.

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