Nucific Bio X4: 2024 Probiotic Supplement Review Research

Nucific Bio X4 probiotic supplement is formulated by Dr. Amy Lee who features the four-in-one weight loss gut health product as part of her 3 Harmful Foods wellness video.

Full Disclosure

Nucific BIO X4 is a four-in-one weight management probiotic supplement created by Dr. Amy Lee to help the digestive system work more effectively to promote fat burning slimming effects, suppress appetite and boost metabolism.

Let's review Bio X4 by Nucific and research Bariatric Physician Dr. Amy Lee's 3 Harmful Foods presentation to see what the facts say about this probiotic formula's benefits.

Find the Best Price for Nucific Bio X4 Probiotic Supplement on Amazon


What is BIO X4?

The Bio X4 probiotic formulation by Nucific's Dr. Amy Lee is meant to help the body naturally slim down without the reliance on dangerous prescription drugs or without having a radical overhaul of lifestyle changes that making being healthy and dieting a daunting task. By avoiding these impossible-to-maintain diet plans, Dr. Lee believes the addition of her Bio X4 supplement to compliment her 3 Harmful Foods regimen is a great way to curb hunger cravings while increasing energy levels and optimizing digestive health.

For most, losing weight can feel like an ongoing struggle, especially when the individual seeking success continues to reach roadblocks and plateaus that keep them from success. Eating a healthy diet and maintaining a regular exercise program are just a few ways that the average consumer can do something about their weight. However, if the gut is imbalanced and filled with toxins, even the most stringent diet leaves consumers with little they can do, but BIO X4 can help with what is commonly termed leaky gut syndrome.

BIO X4 was formulated by Dr. Amy Lee to be a catalyst for shrinking your waistline by targeting belly fat specifically. It includes many helpful ingredients that can create the necessary environment for weight loss and body fat management. According to the official website for the supplement, it should be able to:

  • Manage the user’s weight by supply nutrients that make you feel satiated
  • noticeably reduce cravings and lower the need to overeat
  • Increase the metabolism so your body burns food optimally for more energy
  • Improve digestion to be free of gas, irregular bathroom visits and bloating

Dr. Lee has a history of being involved with internal medicine, focusing on the nutrition, wellness, and other key factors of consumers that need support for weight management. Board-certified by the American Board of Internal Medicine, she is also a member of the National Board of Physician Nutrition Specialists and the American Board of Obesity Medicine. Through teaching her patients and offering new details about the way the body works, she hopes to establish a diet plan that is based on science that can become the new standard in good health.

Within this program, there are some key lessons consumers will learn about the way that the digestive system works and how it can be improved. While there are many health foods on the market today, Dr. Lee describes the way these foods actually cause more harm than good in a presentation on the Nucific website. It also discusses foods that are optimal for digestion, including herbal supplements.

What Ingredients are Used in Nucific Bio X4?

To give the user the experience that Dr. Lee advertises, the formula for BIO X4 includes several blends that aim to make a difference for the user’s body. Dr. Amy's Bio X4 probiotic supplement formula contains 12 billion CFUs of gut-friendly bacteria from 5 unique strains that is meant to rebalance your gut flora's ecosystem and restore gut lining health to prevent leaky gut side effects.

The blends include:

  • Probiotic Blend

The Probiotic Blend, which includes a variety of probiotic strains, creates a healthy environment for the gut to promote better digestion. The body typically has a balance of healthy bacteria in the GI tract, but this balance can be disrupted with the wrong foods in the diet. The Bio X4 probiotic blend portion of the formula has three studies linked to its effectiveness which can be found here (A controlled, double-blind, randomized study on the efficacy of Lactobacillus plantarum 299V in patients with irritable bowel syndrome),
here (Obesity-associated gut microbiota is enriched in Lactobacillus reuteri and depleted in Bifidobacterium animalis and Methanobrevibacter smithii) and here (High polyphenol, low probiotic diet for weight loss because of intestinal microbiota interaction).

  • Digestive Enzyme Blend

The Digestive Enzyme Blend, which includes amylase, bromelain, and lipase, helps consumers to properly absorb simple sugars and fats, while avoiding inflammation. These three prominent digestive enzymes are also backed by medical literature supporting its cause as being a worthy addition to the Dr. Amy Lee's Bio X4 supplement. See the studies on amylase, bromelain and lipase respectively.

  • Weight Management Blend

The Weight Management Blend isn’t really a blend at all. Instead, it simply offers green tea extract, which has been used in weight loss supplements for its boost of the metabolism. Green tea also offers antioxidants to eliminate free radicals that can build up in the body and impede the digestive process. See the two studies on green tea's catechins and EGCG.

  • Craving Control Blend

The Craving Control Blend also contains just one ingredient, the Caralluma Fimbriata extract. Caralluma Fimbriata has been used in South India as a way for women to lose weight for its ability to suppress the appetite. Typically useful for men and women alike, this type of extract boosts the metabolism and promotes effective weight loss. Here is a study investigating the appetite suppression effects of caralluma.

Between these different blends and ingredients, consumers should have the necessary support to burn fat and lose weight, all while creating a healthier environment in the body.

Here is an up-close look at the Nucific Bio X4 supplement facts label that shows each of the four blends dosage and potency levels:

nucific biox4 supplement facts label

Frequently Asked Questions About BIO X4

Here are some of the answer to the common questions that consumers have about BIO X4.

Q: Who is Dr. Amy Lee?

A: As a board certified doctor by the American Board of Internal Medicine®, Dr. Amy Lee is Nucifics lead product formulator for BIO-X4. She is also the creator of the 3 Harmful Foods presentation when first debuted in the summer of 2016 and got really big press coverage back in August 2017.

Dr. Lee is also a proud member of the American Board of Obesity Medicine and National Board of Physician Nutrition Specialists which gave her the insights to practice internal medicine with a focus on nutrition, weight management (obesity medicine) and overall wellness. Dr. Amy Lee's 3 Harmful Foods video is a compelling presentation that refers to the three foods gone bad and highlights the number one drink to avoid as well as the number one carb to avoid along with using the four digestive helpers to add to your daily diet along with the BioX4 probiotic supplement.

Q: What are the Dr. Amy Lee's 3 Harmful Foods to Avoid?

A: The Bio X4 probiotic supplement by Nucific is presented in the form of a video featuring product formulator Dr. Amy Lee and her 3 Harmful Foods guide. During the course of the lengthy health, nutritional and whole body wellness video, Dr. Amy Lee's 3 Harmful Foods reveals sweetened yogurt, wheat bread and cereal bars as the three worst dietary choices you can make in 2024 if you want to proactively manage your weight and energy levels. The one common denominator all three of these harmful foods have when in your diet is High Fructose Corn Syrup. Dr. Lee also alludes to other harmful food ingredients like additives, flavorings, colorings and preservatives.

As you can see, Dr. Amy is big on whole eggs, lentils, avocados, kim chi and dark green vegetables.

Q: How many bottles of BIO X4 are necessary?

A: According to Nucific, the majority of Bio X4 consumers elect to order three bottles at a time, giving them three months of the treatment. However, consumers that want to simply test out the regimen may opt for one bottle at first, while consumers that want to get the lowest cost per bottle should order the six-bottle package which Nucific gives the best discount on its Bio X4 probiotic supplement offers. Also remember BioX4 is not sold in stores and is only available online at either or

Q: How much of BIO X4 should be taken per dose?

A: The daily recommendation is one capsule with each meal of the day. Preferably, the user should take this supplement every day for the benefits but missing a dose won’t create a problem for users.  While 2 capsules per meal can be taken, Nucific specifically recommends Bio X4 users not to exceed six pills per day.

Q: Are any side effects associated with the use of Nucific BIO X4?

A: At this point, there are no known side effects of using the supplement. All of the ingredients are pure and help the digestive system. However, consumers that currently take a prescription medication may want to speak with their doctor first. The Bio X4 probiotic pills contain no lactose and no fillers, are made from vegetarian capsules and 100% pure ingredients.

Q: How long does it take to get results from BIO X4?

A: While results can vary from person to person, Dr. Lee recommends taking the supplement for at least 60 days to see a reaction. According to Nucific, Bio X4's daily use will help not only supply new gut health-promoting nutrients, but also work to eliminate and rid the body of toxic substances and harmful metabolic byproducts that wreak havoc on the body if not properly flushed and removed as it is only excess waste not contributing the the body's well-being.

Q: How Much Does Dr. Amy Lee's Nucific Bio X4 Cost?

A: The only way that consumers can get ahold of BIO X4 is by making a purchase through the official website. Consumers can choose from several package options, including:

  • One bottle for $49
  • Three bottles for $129
  • Six bottles for $240

Even if the product doesn’t work to the user’s advantage, their purchase is covered with a 90-day money-back guarantee.

Any other questions can be referred to the customer service team.

Contacting the Creators of BIO X4: Nucific

Even though the website offers a lot of information, it is possible that consumers will want to know additional details before they are prepared to make a purchase. The customer service team can be reached by calling 800-446-1303.

BIO X4 Summary

BIO X4 is an option for any consumer that needs a little help with their weight loss. With multiple blends available in each dose, the formula can help with the needs that the digestive system has in order to lose the weight that the user is trying so hard to shed. While this formula isn’t technically marketed as a weight loss supplement, details online indicate that it is a “weight management probiotic,” creating a healthy environment for weight loss as necessary.

Check the Best Price for Dr. Amy Lee's Nucific Bio X4 on Amazon

Live Healthier
Advanced Living is a leading lifestyle wellness enhancement movement that highlights health awareness, provides educational research and delivers perpetual knowledge on how to live your best life in 2024 and beyond so you can master the art of aging gracefully in this lifetime. From high energy insights on trending news to truth-seeking analysis for supplement reviews, Advanced Living exists to optimize your well-being universe and act as a genuine guide for personal transformation, spiritual enlightenment and essential wholeness. may receive a small reward on product purchases using links within reviews. For optimal transparency, see the full disclosure on how this process works to support our team’s mission of creating Advanced Living for you.


Please enter your comment!
Please enter your name here content provides generalized information only for education and entertainment. In no way is the content here a substitute for qualified medical advice. Always actively seek a professional dietitian, certified nutritionist, licensed specialist or your doctor for specific consultation before using any supplement our team reviews.

Get in touch at [email protected] with any trending news, tips or review suggestions. Disclosure: link references clickthroughed can result in referral rewards to support our team.

More Supplement Reviews and Product Research

Reviewing the Top 20 Best Wrinkle Creams That Really Work in 2024

While beauty is in the eye of the beholder, getting older in age naturally brings its own set of challenges to combat as proactiveness...

Top 10 Best Garcinia Cambogia Supplements in 2024

Is Garcinia the Most Famous Weight Loss Supplement Ever? Garcinia Cambogia is one of the most well-known ingredients in the supplement market, known for its...

Top 10 Best Forskolin Brands in 2024

As scientific research supporting the efficacy of Forskolin has continued to pile up over the past decade or so, there now exists a mountain...

Top 20 Best Male Enhancement Pills in 2024

Male Enhancement in 2024 and Beyond: Growing Pains Everyone's talking about male enhancement, but let's really talk about 'enhancing a male'. It has been said a...

Top 5 Best Cocoa Flavanol Supplements in 2024

The cocoa flavanols story is quite impressive. Before we get into reviewing the top 5 best cocoa flavanol supplements in 2024, it is important...

Intermittent Fasting 2024 Guide: IF Diet Plan Types and Weight Loss Benefits

Intermittent Fasting in 2024: Beginner’s Guide to IF Diet Plans and Health Benefits Intermittent fasting is one of the hottest diet plans in 2024 and...

Top 10 Best Leaky Gut Supplements in 2024

The ultimate leaky gut syndrome guide features the top 10 best leaky gut supplements in 2024 that are designed to promote optimal gut health...

Supplements Revealed: Watch the Documentary Film Movie Trailer Now

Supplements Revealed is a 9-part documentary series launched online by Revealed Films. The series teaches anyone how to get relief from their health problems and...

Top 20 Best Hair Growth Vitamins and Hair Loss Supplements in 2024

Reviewing the Top Hair Loss and Hair Regrowth Remedies of the Year For both men and women, the ability to have a good head of...

Top 12 Best Keto Shakes to Review and Buy in 2024

In its most basic sense, a ketogenic shake can be thought of as a powdered supplement that can be mixed with either water or...

Top 10 Best Keto Diet Pills in 2024

The Ketogenic diet is one of the most popular nutritional plans in the world. With a focus on promoting a low-carb, high-fat diet with...

Top 10 Best Turmeric Supplements in 2024: Benefits and FAQ Research Guide

Several antioxidants currently on the market can provide major health benefits, but there is only one vividly golden yellow-orange spice that can do it...

Top 10 Best Vitamin D Supplements in 2024: Benefits & Deficiency FAQ

Vitamin D is the sunshine vitamin that is essentially more well-known for its source than it is for its use in the body yet...

Top 10 Best Lung Health Supplements for Natural Breathing Benefits in 2024

The lungs are one of essential to keeping toxins out of our bloodstreams as we breathe, and they also ensure that the body only...

Top 5 Pycnogenol Supplements in 2024: Best French Maritime Pine Bark Extracts

In its most basic sense, Pycnogenol® is a medicinal extract that derived from the bark of French maritime pine trees. It is a highly...

Top 10 Best Aloe Vera Supplements in 2024

Aloe vera is an ancient herbal powerhouse that has been used for ages and ages for its medicinal properties. From it's collagen-boosting, silica-rich nature,...